Transcription Factors Pcr1 and Atf1 Have Distinct Roles in Stress- and Sty1-Dependent Gene Regulation
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چکیده
منابع مشابه
Transcription factors Pcr1 and Atf1 have distinct roles in stress- and Sty1-dependent gene regulation.
The mitogen-activated protein kinase Sty1 is essential for the regulation of transcriptional responses that promote cell survival in response to different types of environmental stimuli in Schizosaccharomyces pombe. Upon stress activation, Sty1 reversibly accumulates in the nucleus, where it stimulates gene expression via the Atf1 transcription factor. The Atf1 protein forms a heterodimer with ...
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BACKGROUND The evolutionally conserved MAPK Sty1 and bZIP transcriptional activator Atf1 are known to play a pivotal role in response to the reactive oxygen species in S. pombe. However, it is unclear whether all of the H(2)O(2)-induced genes are directly regulated by the Sty1-Atf1 pathway and involved in growth fitness under H(2)O(2)-induced stress conditions. METHODOLOGY/PRINCIPAL FINDINGS ...
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ژورنال
عنوان ژورنال: Eukaryotic Cell
سال: 2008
ISSN: 1535-9778,1535-9786
DOI: 10.1128/ec.00465-07